迷迷糊糊的疱疹系列研究----先从感叹开始 [复制链接]

这两幅治疗疱疹的药都到了临床二期了， 过了三期就差不多了， 快了， 希望三期别失败， 加油！！！！

迷糊


AIC316 and CMX001 are in the pipeline -- Phase II, presumably entering Phase III and then the market all going well. These should prove much more effective than current antivirals on the market. There are a bunch of threads here indicating some 20 or so treatments and 'cures' under development.
CMX001 treats 'all 5 families of dsDNA viruses' - this includes all herpesviruses, the 'pox' viruses, adenoviruses, and interestingly the papillomaviruses.

http://en.wikipedia.org/wiki/DsDNA_v..._dsDNA_viruses

HPV is the most common STI out there, and the current single vaccine on the market, Gardasil, is a somewhat questionable treatment -- if CMX001 has a safe side effect profile, it could easily become the treatment of choice for a whole bunch of things -- people could throw a course of them back once in a while to deal with anything they may have picked up.

Interesting the trials are only on people with life-threatening conditions, though, that's presumably the only ethical way through Phase I and II trials -- if they're possibly going to die anyhow or have a life-threatening condition, the drug can't make them much worse and might make them better.

CMX001 uses an existing drug (Cidofovir) and only applies a new PIM delivery technology to it, it seems, which reduces its toxicity... (ditto for CMX157)

The efficacy of AIC316 or CMX001 and low toxicity in Phase II trials might lead to them being fast-tracked -- and the more people who trial the drugs early on, the more we'll hear about side effects.

这一段说的是现在美国发明了一种新型的避孕套， 套子上面有药， 这样性病就不传染了， 疱疹也不传染了， 快上市了。  但我估计这种避孕套可能会很贵 所以大家要努力赚钱啊， 特别是大男人啊， 你们要加吧劲啊！！！

迷糊


vivagel news
I found this trolling on the Yahoo finance message boards:


Starpharma, Rising Star? FNArena News - May 25 2011

- Starpharma is a leader in dendrimer technology
- Demdrimers offer potential for platform technology
- VivaGel product to generate first revenues this year
- Southern Cross Equities rates Starpharma a Spec Buy

By Chris Shaw

Starpharma (SPL) is a leader in developing polyvalent nanoparticles known as dendrimers, which are precisely and uniformly constructed large molecules. The company's lead product is the anti-microbial compound SPL7013.


This product, branded as VivaGel, is being adapted as a coating for condoms and as a protective against sexually transmitted infections (STIs), with Southern Cross equities expecting first revenues from VivaGel to be generated this year.

Southern Cross rates Starpharma as a Speculative Buy, seeing significant upside from VivaGel given the large scale of STIs around the world and the fact the product can be applied by women to protect themselves.

Two recent announcements support Southern Cross's positive view, one being the licensing of VivaGel as a condom coating to Japanese condom maker Okamoto. Southern Cross notes the Japanese market is worth US$500 million annually, with Okamoto enjoying a 55-60% market share.

As well, Starpharma has recently announced Phase II clinical trial success with VivaGel in treating bacterial vaginosis. Southern Cross suggests success here potentially opens up a market worth at least US$300 million annually, with scope for a filing for regulatory review in 2013.

As VivaGel posts positive results this increases the potential for dendrimers to develop new markets as drug delivery agents, leading Southern Cross to suggest the technology can become a platform technology.

This implies potential for the development of a number of earnings streams in coming years. This is especially the case if VivaGel can be shown to help prevent a range of STIs such as genital herpes, HPV and HIV.

Trials to prove this would likely be costly, Southern Cross estimating an HIV efficacy trial would require as many as 4,000 subjects. This implies a cost of US$60 million, so any such trial would likely require some government funding.

Using conservative assumptions for royalties from Durex, where a VivaGel coated condom is being commercialised and will be released this year, and ascribing some value to other programs, Southern Cross values Starpharma at $1.87 per share. Factoring in more optimistic assumptions sees this valuation increase to $3.68 per share.

As commercial interest in Starpharma's products and technologies increases, Southern Cross analyst Stuart Roberts expects the share price to re-rate to this valuation range. This implies good value in the stock at current levels. Such a re-rating may commence in the shorter-term given the upcoming launch of the Durex VivaGel coated condom.

Additional value is likely related to further dendrimer developments, Southern Cross noting the market is a fast growing one and Starpharma has the ability to make dendrimers at what are reasonable commercial prices.

Starpharma is already involved in developing dendrimers for the fields of agrochemicals, animal health and water treatment, which Southern Cross suggests shows the potential upside from new markets if further successful products can be produced. Increasing the chances of such success is the fact Starpharma is already collaborating with Big Pharma on drug delivery technologies.

Southern Cross has a valuation-based price target on Starpharma of $1.90, which implies upside of around 30% from current levels. Shares in Starpharma today are weaker, trading down 4c at $1.425 as at 11.20am. Over the past year Starpharma has traded in a range of $0.48 to $1.525.

---So Starpharma expects to start seeing Vivagel revenue THIS year...

又带来了新的消息，其实你就算没有什么消息，过来看一下，大家的心里就会安心好多。呵呵，你自己也要加油哦！

加油， 迷糊也要加油， 先把发烧治好， 看看这回发烧会否把疱疹烧死！！！！！！！！！！！！！！！！！！！！！

想想办法：  我觉得网上邮购的疱疹试剂还是不要买。  别管哪里的， 如果你都花了 6000元了， 还不如飞到香港两千块钱机票加上测试费， 都比你的便宜。  以后别网上买试剂， 记住

多谢胡杨， 好了， 我要吃饭了， 再见

迷糊

姐姐，你有时间接触比较不错的医生的时候帮我问问，母亲有抗体怀孕后生下的健康小孩查血有IGG阳性，是不是传染了呢？还是就应该存在抗体啊，还有就是有抗体的宝宝是以后不会感染PZ啊？谢谢了

姐，我这不是没有办法嘛，我身不由己啊。要能直接去香港或者美国，我也是老早去了。
通过邮购买试剂也是无奈之举…
香港那边我也正筹备着呢，一定要去的，怎么也给自己一个明白。也算为论坛作出一点贡献。
回来我会告诉大家结果，希望我可以逃过一劫吧。

姐，过去就过去吧，留得青山在，不怕没才柴烧。钱，这个世界多了，就看你怎么赚，赔了也是正常，没人敢说自己做生意包赚。以后还可以努力的。

希望姐的主和我的佛都保佑我们！

迷糊姐要是你 帮大家最先找到治愈疱疹的办法 做牛做马我都心甘情愿

艾滋在美国都出现治愈的了，希望PZ也快点吧

姐要搞基金到美国，我第一个捐、

两三天没来了，大家端午节过的还好吧~  同时谢谢迷糊姐姐的一直在为大家默默的付出！