迷迷糊糊的疱疹系列研究----先从感叹开始 [复制链接]

我先不等了， 要带着孩子出去玩了， 香港今天天气真好！！  等你的答复。  

迷糊

不好意思。。。让你久等了。。。

希望你和儿子玩的开心。。。我几次去香港都是为了买东西。。。所以都走得很匆忙。。。最多就是体验一下香港的美食。。。下次有机会去检测一下，顺便好好玩玩吧。。。我也被这个鬼东西折磨得够呛了。。。呵呵。。。姐。。。能麻烦你不要用您吗。。。我比你小。。。而且我很尊重你。。。所以坚持叫姐。。。但是你用您称呼我。。。我感觉压力好大。。。你就当无缘无故多了个弟弟吧。。。哈哈哈。。。

姐，我算想明白了。。。

你所有的报告都没有问题。。。就算有疱疹了你的身体也没有那么多的问题。。。是你想多了。。。

姐。。。你正在更年期啊，身体出现众多不适是很正常的。。。很多症状是更年期女人会出现的。。。不要被疱疹唬住你了。。。多去调理调理身体和做多些运动吧。。。相信接下来你的感觉就没有那么强烈了。。。

你的报告关于IGM的部分我们可以忽略不计。。。那个IFA。。。其实是EIA其中一部分。。。是同一个实验来的。。。不用太纠结。。。而且无论是EIA还是ELISA。。。其实都是差不多的过程。。。只是不知道为什么美国自己说IGM不准还要拿IGM来忽悠我们。。。我18日不是也去验血了吗。。。相差不过半小时抽两次血。。。IGM的结果一样可以一个检出阳。。。一个检出阴。。。

第二次美国的IGG为阴。。。我只能说刚好那次就是假阴了。。。其实，美国也好很多假阴假阳。。。还有一个可能。。。是全盘推算出来。。。

下面再说。。。PCR的阳应该也是没错的。。。虽然也存在假阳现象。。。但是PCR仍为美国比较可信的结果。。。而且也说了。。。女性阴道分泌物即使在没有症状的情况下也可能查出PZ病毒的。。。不过我想不明白。。。怎么下面两种都感染上了。。。你老公是不是有毛病啊？？我不敢说自己去找女人算账。。。因为那是自己自找的。。。但是就像你说的，你老公对你有责任啊。。。我们没有老婆的就算了。。。

香港的检测水平我还是相信的。。。IGM还是那句。。。忽略。。。IGG其实弱阳也就是了。。。大概你当时的数值大概就是0.7以上接近0.8吧。。。至于抗体，我想有时也会因为身体的原因出现滴度低的情况。。。其实IGG的产生是很少量的。。。毕竟我们身体才多大啊。。。人类的身体还有其他很多东西呢。。。

国内的。。。我也忽略不计了。。。因为不知道是什么试剂。。。估计也跑不了国产试剂。。。而且只有IGM项。。。

国内的PCR，因为个人素质和实验设备问题。。。假阴假阳说不清楚。。。国家都不提倡用以作为诊断标准。。。不过即使在国外，也只有症状明显，有水泡和溃疡的时候才可能准确做出来。。。其他时候的结果是不一定准确的。。。

最后说说美国第二次IGG阴的结果吧。。。这个结果应该来说是没错的。。。而且通过整个过程来说不是恰恰好说明你就是去年才得的吗。。。IGM说了。。。没有可用性。。。但是在初次接触史里，试剂够好的话有40%可测几率。。。说明初次感染了。。。然后你在不足以产生IGG抗体的情况下检测了IGG抗体。。。所以结果为阴了。。。但是在初发的话。。。PCR的检测阳性结果可以达到94%。。。就是你一道检测下来的2型PCR阳性。。。

1型的话。。。全世界都有份。。。这个就不要在意了。。。在对话的过程中口水就可以导致感染了。。。而且不一定出现症状。。。就算有症状你也不会是那频繁复发的几个幸运儿。。。结婚后才有皮肤不适。。。这个不好说啊。。。不过你想想啊。。。你一直是一个人过的。。。好好的。。。和另一个人在一起。。。就有了接触。。。身体某部位也发生改变了。。。甚至改变了身周的长期环境和心理动态。。。人体是奇妙的。。。可能这就导致你身体出现变化了。。。就算忽略这个不计。。。人也会忽然间就觉得从某一刻起感觉身体哪里不舒服的。。。但是有找不到原因。。。尤其皮肤。。。和过敏反应拉上关系。。。就更说不清了。。。我身边就一活生生的例子，我表妹读初中好端端的，上高中住宿了就皮肤过敏了，到现在两年多都没好。。。所以13年前到现在你下面一年会痒一两次也不出奇啊。。。很多男同志没有疱疹的一年也好多时候会痒。。。

说到这里。。。不管过程和结果如何。。。姐你也不在意了。。。也说了。。。有两种可能。。。就当你老公是15年前年轻幼稚不懂事得的。。。只是现在终于不可避免地感染你了。。。那你会更好受的。。。心里也不要想太多了。。。有时男人有苦也说不出啊。。。多体谅体谅吧。。。人生苦短。。。却什么都要经历。。。几十亿人才你们两个走在一起。。。也是缘分。。。好好过日子吧。。。

最后的最后，还是要提醒姐。。。你正处于更年期。。。好好调理身体才是正道。。。不要在疱疹上想太多了。。。你的其他症状都是心里作用啊。。。身体调理好了就什么不适都没有了。。。

没有PZ的人生是多么的幸福啊！:'(    做人是多轻松啊！:'(

一切压力和PZ比瞬间变得没了！！！！！！

想开了。。。一切压力都比PZ重的也有啊。。。

没钱了。。。生活穷困潦倒了。。。

甚至更差的。。。

想想都感觉恐怖的。。。

放开心情吧。。。除了难以启齿。。。和内心难受。。。这个病真的没什么。。。虽然我自己也放不下。。。

不过全世界都有了。。。你就不觉得了。。。

确诊了的，都不要想太多了。。。好好活吧。

迷糊姐，请问你们有睡眠不好的问题吗？

迷糊姐我还请教你一个问题，是不是有PZ就一定有盆腔炎呀，我被这些病折腾的受不了了，晚上也睡不好，一个月几次，怎么办我真的想死了算了。

今天带儿子一起玩了海洋公园， 天气挺热的， 我的疱疹又在复发阶段， 而且心情还不好， 所以根本没有什么心情笑。 看着儿子开心， 老娘我也就开心了。  

根本没有心情买东西， 还买什么啊， 钱都被骗了， 自己也要惩罚一下自己， 这次要节约， 不想为自己买任何东西了。  

老公为了这件事情也非常生我的气， 但是这是我自己的生意， 他也没再多说什么。  现在最关键的就是要聘请一位神通广大的律师，他也在为我联系律师， 看来这笔律师费是省不了了， 今年真是我的多事之秋！！！！

也许是例假要来了， 再加上疱疹复发， 再加上被骗这件事， 我不知为什么总想哭！！！！！

要学会控制自己， 大周末的何必呢， 老公做的挺好的， 带我出来散心， 我还要求什么呢？  

不说了。  

看看疱疹， 美国的一个热心的病友昨天发出来帖子， 他把目前美国正在研制的疱疹治愈， 治疗和疫苗的药有重新搜集整理了一遍， 哇， 你们看， 目前有20多种药正在研究中啊， 哪怕当中有一两种成功我们就是正常人了。  同志们， 朋友们， 我们应该快熬出头来了！！！！！！！！！！！！！

坚持住！！！！！！！！！！！！

HSV DRUGS
1. StarPharma (Vivagel) – I think most people will agree based on enormous evidence that this drug will probably be the next to come out, Vivagel is a preventive gel intended for women to help protect them from getting the genital hsv infection, Vivagel apparently is a topical gel applied to the vaginal area which is suppose to kill herpe’s on contact. It has been rumored that a deal between StarPharma & Durex has been made to coat their condoms with Vivagel and it will be released in the near future in Japan & also an agreement with Okamoto another condom maker. Vivagel is in phase II development with the FDA, but I will point out that Japan is not bound by FDA regulations. Latest news was May 23, 2011 : http://starpharma.com/news/68

2. Chimerex (CMX001)- Is an anti-viral which is derived from the currently used drug Cidofovir(an injectible), its main advantage seems to be that for one it is intended to be an oral drug and is not suppose to be as toxic. Tests in animal studies have revealed it may be up to 250 times stronger than Cidofovir without as many dangerous side effects, the main question is if it is released will it be used for HSV. They are currently in Phase II studies, other promising news is that they received a $36.1 grant for their research from the NIH. Latest news was April 15, 2011: http://www.chimerix-inc.com/news-and-resources/news-and-resources-details/needham-and-future-leaders/

3. Sanofi Pasteur, Dr. Knipe & Dr. Halford (Acam-529): Definitely my favorite company right now, I know Dr. Knipe and Sanofi are connected, but cannot verify with certaintity if Halford is involved but his name pops up a lot when acam-529 is mentioned in reports and the media(it is intended for HSV2). What’s interesting about this Vaccine is that it is the only Live HSV vaccine that is scheduled for a phase I study in 2012 in various news reports. Another promising thing about this drug is that how the closest relative to HSV, VZV is vaccinated with a live vaccine. What I find interesting in the news articles is that there is a lot of talk about Africa and its high rate of HSV and HIV contained in every article I can find that mention’s Sanofi’s planned Phase I study, I think they may be planning a large Phase I study in Africa. I think the drug is intended to be both a vaccine for infected as well as un-infected individuals. Sanofi is a huge company and has almost unlimited resources to push this drug through quickly if it works. Looks like a planned conference is scheduled around August 17, 2011 to discuss more about Acam-529: http://www.the-infoshop.com/conference/imvacs11/vac2.shtml

5. Genocea (HSV2)- Genocea is developing both therapeutic and prophylactic vaccines for HSV-2 based on the discovery of antigens with its technology. In in vivo preclinical proof-of-concept studies, the antigens have demonstrated protection against disease, reduced viral shedding and lesion recurrence. Although their HSV2 vaccine is still preclinical they recently received $35 million dollars in financing and have partnered with several companies. Latest news was on January 3, 2011 : http://www.genengnews.com/gen-news-highlights/genocea-pockets-35m-to-progress-preclinical-t-cell-vaccines/81244453/

6. AMGEN (Immunovex2) – Recently purchased by Amgen from Biovex, Immunovex2 is intended as both therapeutic and preventive vaccine for HSV2. A Phase I study was started in February 2010, but completion and/or results are unknown. The bad news is that AMGEN bought Biovex mainly for its cancer drug, the good news is that AMGEN recently acknowledged the existence of Immunovex2 and briefly discussed it, sort of implying they are working on it. Also AMGEN has the money to back up any research study if it chooses to do so. The latest news was on March 7,2011(you will have to register to listen to this conference((it mentions and I quote “"It is interesting that we are able to remove two of the Herpes Simplex proteins".)) ) : http://www.wsw.com/webcast/cowen3/register.aspx?conf=cowen3&page=amgn&url=http%3A//www.wsw.com/webcast/cowen3/amgn/

7. VICAL (HSV2) – Another one of my favorite companies, they seem to release news almost weekly lately. Their HSV2 vaccine is intended for already infected individuals to be a permanent suppression and to work on individuals who are not infected. They have two patents, which leads me to believe they may be working on two different variations of the drug. Although it is in pre-clinical trials, Vical has a lot of money to spend, has no debt and is aggressively seeking partners and has succeeded in obtaining them on most of their other drugs in development. They recently hinted that HSV2 was probably going to be their primary focus after they finish their cancer drug and CMV drug which are both almost finished and also leaked out that they we’re in discussions with partners on their HSV2 vaccine. Their latest news came on May 16,2011 in a webcast conference: http://noble.mediasite.com/mediasite/SilverlightPlayer/Default.aspx?peid=e99265127b01471480c23b34b1c801d1 1d

8. AICURIS (AIC-316)- AIC-316, intended for HSV2 is suppose to be a therapeutic drug that is suppose to stop all viral shedding and could prevent the transmission to others, possibly making it a permanent suppression drug. What I don’t like about this company is it is most likely small and we don’t really know their financial situation since it is a privately held company and the fact they said they we’re going to release findings sometime early in 2011 on the Phase II study that was finished in December 2010. What I do like is ofcourse the fact they have made it to phase II and completed it, but whether it was successful or not is of concern, since they haven’t even told us that they are either still studying it, talking to partners or it was a failure. I hope Aicuris will say something soon. The last news I have on the company came on December 8, 2010: http://www.aicuris.com/10d46/News_Publications.htm

9. AGENUS (HerpV) – HerpV also known as AG-707 is an interesting vaccine intended for HSV2 where that it attacks the virus by producing more CD4 and CD8 Killer T cells. What I like about this vaccine is that it is definitely unique in how it operates, it could potentially cure HSV. It also had (although small) a very successful Phase I study. Its major obstacle is funding it seems, I almost have to think they will have to get a larger pharmaceutical company to back them up. Their financials are not very good. But things could turn around quickly if they get someone to back them up or possibly grant funding for their research. The latest news I have on them is July 27,2010 : http://www.agenusbio.com/docs/herpv/0727.pdf

10. CELLECTICS (HSV1) : Don’t know much about this one, it uses a technique called virus clipping also known as meganucleases, it is suppose to be a preventive, but may work as a cure. I do not no its mode of delivery but suspect it’s a vaccine. The good news is this seems to be a pretty good financially sound company and I believe they have the money to back up any research. The latest news I have on this drug is dated January 19, 2011: http://www.cellectis.com/sites/default/files/110119_MolecularTherapy_EN_0.pdf

11. PEREGRINE (Bavituximab) : Currently in Phase II clinical development against hepatitis C virus (HCV), bavituximab is the first in a new class of patented antibodies that target and bind to the cellular membrane component phosphatidylserine (PS). PS is a highly immunosuppressive molecule usually located inside cells, but which becomes exposed on the outside of the membranes of certain viruses and virally infected cells, creating a target for antiviral therapy. There has been some belief that this is a wide spectrum drug and could be used to treat many virus’s including the Herpe’s strains of virus’s, more in particularly CMV, but some scientists suggest it could cure HSV by eliminating the sensory neurons. Now whether this would be good on the body I do not really know. The latest news I have on this is April 1, 2011: http://docs.google.com/viewer?a=v&q=...8lUOq60A&pli=1

12. ALPHAVAX (HSV2) – This comes directly from their website: AlphaVax is developing prophylactic and therapeutic alphavaccine products focused on the sexually transmitted form of HSV. These products are leveraged by 6 years of preclinical work showing excellent prophylactic protection in animal models as well as the ability to reduce HSV reactivation and disease severity in state-of-the-art therapeutic disease models. A successful prophylactic vaccine product is expected to require the induction of both antibody and T-cells, which makes HSV an ideally suited target for our alphavaccine platform. Based on successful preclinical work which is now published, AlphaVax is advancing an HSV alphavaccine into clinical testing early in 2010. Following phase 1 safety and immunogenicity trials, a phase 2 proof-of-concept trial may be carried out in "discordant couples" which should provide an early indication of efficacy. I’m not sure what the holdup on taking this to trials, but suspect it is money, they are currently looking for partners. The latest news I have on this vaccine is dated November 4, 2009: http://www.alphavax.com/docs/pr/release_59.pdf

13. NANOVIRICIDES (HSV1 & HSV2): Is an anti-viral Topical ointment as well as possibly a pill. Has been shown in studies to kill the HSV virus and has the potential of possibly killing the virus permanently. Not a lot is known about its action. The latest news I have on this anti-viral is August 10,2009: http://www.news-medical.net/news/20090810/Nanoviricides-anti-herpes-drug-candidate-reduces-viral-load-by-999925.aspx

14. AstraZeneca (Motavizumab)- Is a Monoclonal antibody, it is currently in a Phase III trial. It is intended for treatment and ability to seek out HSV in some studies, but has now been restricted to treat various RSV. Some of the studies AstraZeneca did they have voluntarily withdrawn from FDA licensing. Latest news was December 2010, not very promising news, but AstraZeneca has the money to back up almost any research: http://en.wikipedia.org/wiki/Motavizumab

15. CYTOGENICS (Simplivir) – Is a topical cream that works a little differently by that it attacks and cancels the reproduction of the virus and supposedly keep it from migrating to nerve cells. This company has an interesting approach, but I think it will be a while before anything new develops. They claim of a hundred fold decrease in viral load in rats. Latest news I’m aware of was on March 2, 2005, Although they did apply for a patent in 2008 that I did not link to(since it has no viable info): http://www.cytogenix.com/en_us/Company/pr_simplivir.html

17. MYMETICS (HSV1 & HSV2): a Vaccine in early stages of development, this is taken directly from their website; Exploratory experiments were performed on mice in which the immunogenicity of HSV-1 virosomes is investigated, following injections through various routes (intra-muscular and intra-nasal).
The next stage of research will focus on the development of new virosomes. If results are confirmed, up-scale and GMP production will be investigated with mandatory toxicity evaluation in animals. A small Phase I clinical trial in a population of seronegative subjects to HSV to assess the safety and tolerability of the vaccine should take place soon after toxicology studies.

18. Biomedical Research Models (HSV2): Currently working on a vaccine for HSV2, received a nice large grant for their research. Not much known about this company. Latest news I have is dated February 23, 2009 : http://www.biomere.com/pdf/2009-grant-press-1.pdf

19. VIRONOVA (VN-180) - Therapeutic Antiviral - Vironova’s lead compound, VN-180, is a CAI which acts to block the formation of the virus particle, thus inhibiting newly replicated viruses from maturing and becoming infectious. This unique broad range Herpes antiviral has been developed significantly faster than industry average utilizing Vironova’s virus analysis technologies. VN-180 has been presented to major pharmaceutical companies and discussions will proceed during the development of the project. The good news I suppose is that this drug is intended to be used for all Herpe’s class’s of drugs 1-8, has the potential of being a wide spectrum anti-viral I suppose kind of like CMX001. The latest news I have on VN-180 and I’m not sure since it pertains to it, since a lot of it is in Swedish and I do not speak it is on November 13, 2008 : http://www.mynewsdesk.com/se/pressroom/vironova/video/view/vironova-virus-diagnostics-and-antiviral-drug-development-803

20. CEL-SCI (Herpes ((HSV?)): A Vaccine that uses peptide immunogens to get a better immune response also involves the C4 T cells. This is in early preclinical trials. Seems like it would target all family of Herpe’s virus’s. The latest news I have on this company is dated October, 1,1997: http://articles.baltimoresun.com/1997-10-01/business/1997274001_1_vaccine-herpes-infections-herpes-simplex-virus


Other’s worth mentioning:

Dr. CULLEN & Dr. BLOOM : They we’re working on a study with rabbits for HSV2 research, and were suppose to be finished in February 2011, but have yet to post any info, led by bloom. They are now seemingly working on HSV1. But have never released any findings on either. These people have been working either together or separately since 1999. Maybe more funding would help them or a partner, wonder what might be scaring partners away (if that is the case). This is the latest research I have on them dated January 12,2011: http://www.herpescureresearch.org/jan-12-2011.htm March 7, 2011 : http://www.herpescureresearch.org/mar-07-2011.htm

Dr. IAN FRAZIER : The founder of the HPV vaccine made Australian of the year for this work. Has a strong interest in HSV research. Will be head of a new research facility, the largest in Australia, He will have a lot of funds and people at his disposal, now whether or not he will utilize it for HSV research remains to be seen.


加油， 大家
迷糊

今天特累， 我一会就睡了， 大家晚安

睡之前回复下朋友的帖子。  

我是天天开心：  疱疹会引起并发症盆腔炎， 就是腹部和附件， 有时波及盆腔疼。  通常初发的第一， 二年这宗情况比较严重， 但是过了最初的两年， 症状就会慢慢好转。  你如果有盆腔炎， 就吃些这方面的消炎药， 那是炎症一定要去治理。  待疱疹的病毒没有那么大威力而导致复发减少时， 你的妇科病也就慢慢会好起来。  

女人有妇科病很正常。  这些并发症没什么的， 就像男人许多人有疱疹同时有前列腺炎症一样。  有病治病， 千万别想不开。  去寻死的人是懦夫， 没有人同情你。  再过几年就都好了， 你说你现在去寻死， 多不值得！！！！！！！！！！！

所以不要去想那些最不吉利的。 想想你以后有可能拥有的最好的东西。  多想正面的， 你就正面了！！！

女人多笑， 男人也会更爱， 大家都笑起来！！

想想办法， 多谢你的细心分析。  总之， 你是一个会解玲的人， 什么事情让你一说就会轻松点。  不管是一型二型， 我相信过不了几年就会被我杀入十八层地狱！！！！！！  疱疹， 去死吧！！！

药就要来了！

迷糊

辛苦您了，迷糊姐，您总是那么热心。今天碰上您真不容易。哈哈