迷迷糊糊的疱疹系列研究----先从感叹开始 [复制链接]

迷糊姐，你好！
刚才我打电话去省艾滋病预防控制中心了，工作人员说关于阴滋病国家卫生部已经发文批谣了。至于那些舌苔长毛的病友，应该是其它疾病或者就是什么新病毒感染吧。
迷糊姐，我很赞成这个想法，非常赞成，我也非常想加入请求钟愿士帮助的这一个集体。只要有地址，给他写信或是电子邮件我都愿意做。真的希望国家能帮帮我们！

终于来了一个关于新药的新消息。 主要针对乙肝， 丙肝等， 但是对于治疗病毒的一大推进， 同时对疱疹有用。  由于是附带治疗疱疹， 我就不翻了， 你们试试理解。  

永远记住一点， 科技在进步， 每一天都会有新的成绩， 相信科学。  我有信心疱疹的治愈就是不久的几年。  库伦都说了， 治愈的药已经有了， 就是还不敢在人体身上用。  所以他肯定的说治愈的药就是现在。  相信他绝不是心口开河！！杜克大学绝不是骗子。  

主保佑，
迷糊



New herpes treatment shows promise
April 2, 2011
Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV
infection
Promising new viral hepatitis data presented today at the International Liver CongressTM show that
entry inhibitors --a new mechanism of action for drugs to treat viral hepatitis -- could provide the
first new hepatitis B and hepatitis D treatments for many years.1,2
Most current approved therapies directly target viral replication (e.g. nucleotide/side analogues), and can
lead to the development of viral resistance or viral rebound after the end of treatment. Entry inhibitors
prevent the virus from entering the cell and forming a stable replication complex, limiting the issue of viral
rebound and resistance development.
Professor Heiner Wedemeyer, EASL's Secretary General, commented: "The current treatments available for
hepatitis B & D are limited. These novel drugs are the first promising treatments for many years. The shift
in the mechanism of action of these drugs from inhibiting the virus's replication directly to inhibiting its
entry into the cell, and thus its replication – means they are less likely to produce viral resistance; a
huge problem faced by many of today's clinicians."
One study1 showed that treatment of ex-vivo liver cells with synthetic anti-lipopolysaccharide peptides
(SALPs) during and prior to HBV infection was highly effective and dose dependent in inhibiting infection
– reducing markers of HBV infection (e.g. HBV RNA, HBV antigens) in the concentration range of
4-5 µg/mL by 90% and 0.5-2 µg/mL by 50%.
The study also demonstrated that SALPs showed activity against other viral (e.g. HIV, herpes) and
microbial (e.g. peritonitis, colitis and pneumonia) infections. Therefore, SALPs represent a very promising
therapeutic strategy to treat viral hepatitis infection and concomitant bacterial infection – which often
leads to life threatening systematic complications.
Other studies2,3 illustrated the enormous value of the chimaeric mouse model of chronic HBV and HDV
infection for the preclinical evaluation of antiviral drugs. The study demonstrated that the HBV entry
inhibitor Myrcludex-B was able to completely block the spread of HBV from cell to cell and to prevent
de-novo HDV infection of human hepatocytes.
Professor Wedemeyer commented: "Although there are 35 million people around the world with HDV
infection there is currently little to offer them therapeutically. I am therefore delighted to see these new
drug developments."

lookagain,

感谢你的分享， 我心里踏实了点。  这两天总疼， 例假要来了， 疱疹也要来了。  

这个不速之客我还真拿他没办法。  送客吧！

长期疼也会担心由功能性病变转为器质性的。  不去想了， 再等几年一切就是过去时

主保佑
迷糊

it basically means that it won;t let the virus reproduce or get immune to the drug you are given. Once it kills it it keeps killing until it is gone. it cannot reproduce or in the case of hsv or vzv it cannot go into latency and then come back out, this is in theory since it is taylored towards hbv and hdv.

再次强调以上消息绝对是个好消息， 是最终治愈病毒感染的前奏曲。  

看来黎明前黑暗不会太久了， 战友们， 我们一定要坚持住， 光明就在前头！！

主保佑我们
迷糊

战友们， 同志们， 今天怎么那么多好消息啊！！

简直是太振奋人心啦！！！！

这个清明节没有白过， 我们的老祖宗看来显灵啦， 你们是否去崇拜啊？  没有崇拜的一定要去拜拜先祖啊！！

带状疱疹疫苗成功了！！！！！！！！！！！！！！！！

这个月正式获得美国药监局通过就要上市啦！！！！！！！！！！！！！！！！！！！！！！！！！！！！

Did you know that there are more than 100 different types of Herpes Virus’s (this includes both animal and human).
For Simplistic reasons I will list the most common Virus’s and what they are along with their acronyms:

HHV-1 : Herpes Simplex Virus Type 1 (HSV-1)
HHV-2 : Herpes Simplex Virus Type 2 (HSV-2)
HHV-3 : Herpes Zoster, Shingles, Chicken Pox (HZV)
HHV-4 : Epstein Barr Virus (EBV)
HHV-5 : Human Cytomegalovirus (HCMV) or (CMV)
HHV-6 : Roseolovirus, Herpes lymphotropic virus, Herpes Type 6
HHV-7 : Roseolovirus, Herpes lymphotropic virus, Herpes Type 7
HHV-8 : Kaposi's sarcoma-associated herpesvirus (KSHV)

Most people probably don’t know this, but most of these Virus’s not just HSV-1 & 2 are treated with anti-virals like acyclovir.

Now back to the Two and only vaccinations, The Vaccinations are called Varivax which is used for chicken pox(very similar to Shingles) and is mandatory in most schools in the USA to take, it is about 80% effective and was approved in 1995 by the FDA and the other is called Zostavax it is for Herpes Zoster(Shingles) is about 50% effective and was approved in 2006 by the FDA, both are made exclusively by Merck & CO. Some of you might think I’m wasting your time by posting this but the important thing to remember here is a recent development just happened on :
March 24, 2011, This drug(Zostavax) was until then approved for people age 60 and older. The FDA on March 24, 2011 and that’s just 7 days ago approved it for use for people aged 50 and over.

Now lets put this in a broader perspective, currently companies are working on vaccines/cures for HSV1, HSV2, a better HZV, EBV, CMV and probably the others I have listed.

We are getting closer folks especially with the recent FDA approval just a week ago of the Shingles Vaccine.

What I’m trying to do is gather intelligence on these Herpes Types and current work being done on their Vaccines, treatments and cures. I would prefer this thread to be more focused on Herpes virus’s other than HSV-1 & HSV-2.

Any Info would be greatly appreciated. We are getting closer, just one week ago we made a huge step, and its time for the next step, the next approved vaccine, drug, cure, this in my opinion will bring us closer to the step most of you are probably preferring the HSV-1 & 2 Vaccine.

顺便说一句， 不是我挑刺， 我们坛子上的置顶文章， 有些理论是要更新和订正的。  人绝不是疱疹病毒的唯一宿主！！！  

特此更正， 其实置顶还有一些其他的说法我也不同意， 但我尊重人家的文章， 我不去批判更不会去删他的帖子。  没有这个权利， 即使有也不会去用这个权利

太好啦！！！！

主保佑大家
迷糊

昨天扫墓坟前祈祷疱疹早日离开，希望我们大家的祖宗都来保佑我们。我们也应该积德行善，多做益事好事。

迷糊姐，你终于回来啦。好想你
:$

确实是振奋人心的好消息 不过那是用于60岁以上老人的 带状疱疹疫苗 以前我也早说过了 距离HVS恐怕还有相当长的一段路要走。  库伦都说了， 治愈的药已经有了， 就是还不敢在人体身上用。  所以他肯定的说治愈的药就是现在。  相信他绝不是心口开河！！杜克大学绝不是pian子。  

有什么不敢的啊 既然动物身上米事 估计人也应该没事，其实 治疗疱疹的药 有很多都已经在动物实验身上 但是没人用在人身上 估计都是怕PZ这个小毛病 用了药之后产生大的副作用  不过不用怕 既然药物成功 就肯定有志愿者愿意试试 ，其实美国也有和我们心态一样的战友:) 肯定有愿意充当小白鼠的  问问中国的战友 肯定有不少人都愿意尝试何况美国呢， 大家也不用怕等美国人治疗好 而且没有并发症 再进入中国 一时半会没这么快 ，还要通过检查和认证的。是国外的人充当小白鼠 哈哈;P
理论上我认为 库伦 的研究是可行的 我的疱疹6年很规律 但是一次住院 严重爆发了一次  一直冒泡 和大面积爆发别的没什么 没有产生是副作用   所以我相信 动物没问题的话 人也应该没问题（实在不确定的话多找些动物做实验比如 猴子 黑猩猩之类的）灵长类动物最合适

哈哈真的是好消息了，快了大家保持好的心态吧

疱疹疫苗herpv和 immunovex已经进入临床一期， 再有两期没失败就可进入市场。  有了疫苗， 下一步就是治愈。  这没什么含糊的。  关键是找出了病毒的成分构成明白了机理， 这是cullen教授的重大贡献。  我们拭目以待看看今年， 明年或后年的诺贝尔医学奖颁给谁吧！

HerpV or Immunovex will be the one since they have already finished Phase I clinical trials.

感谢主！！

迷糊

姐!真的吗?我要激动死了。